M-K is a safe anesthesia combination of Medetomidine HCl and Ketamine HCl, that can be used to immobilize a broad range of species. These two pharmaceuticals when used in combination of: Medetomidine (5 mg/ml) and Ketamine HCl (150 mg/ml), provides smooth induction times and excellent recovery. M-K immobilization can be easily reversed after 20 minutes with a single injection of Atipamezole HCl.
This highly effective combined formulation has been used in thousands of immobilizations and controlled studies for many years. As stated by Dr. Harry Jalanka in his noted 1990 study entitled: The Use of Medetomidine, Medetomidine-Ketamine Combinations, and Atipamezole in Nondomestic Mammals: A Review, “Medetomidine, a potent alpha2-agonist, in combination with the dissociative anesthetic ketamine, has been used to immobilize a variety of nondomestic mammals. The recent development of potent and specific alpha2-adrenoceptor agonists and antagonists has enhanced their use in nondomestic animal immobilization and reversal.
“While Medetomidine alone induces sedation in a dose-dependent way, and complete immobilization has been achieved with high doses in non-domestic animals, we feel that ketamine should be added to the immobilization mixture to ensure complete immobilization and operator safety. Clinically, the resulting immobilization is characterized by a smooth onset, good to excellent myorelaxation. We have had no fatalities attributable to this immobilization mixture (1,240 immobilizations).“
The alpha2-adrenoceptor antagonist, Atipamezole, is highly effective in reversing the immobilization induced by Medetomidine-Ketamine combinations. In ruminants, carnivores, marsupials, primates, and rodents the Medetomidine-Ketamine-induced immobilization has shown to be rapidly and persistently reversed with the Atipamezole antagonist.
SOURCE: Harry H. Jalanka and Bengt O. Roeken The Use of Medetomidine, Medetomidine-Ketamine Combinations, and Atipamezole in Nondomestic Mammals: A Review Journal of Zoo and Wildlife Medicine, Vol. 21, No. 3 (Sep., 1990), pp. 259-282.
Published by American Association of Zoo Veterinarians
Indications: Wildlife Immobilization
Our M-K premixed formulation was developed to provide veterinarians and wildlife biologists with a convenient immobilization anesthesia option that is: effective in broad species applications, safe, easily reversible, with a simple / small volume dosing schedule
Uses, dose and efficacy in wildlife was widely known when used with Carfentanil, A3080, Ketamine and Telazol
Application in combination with Butorphanol and Azaperone (BAM) was a new concept in 2003
With a good intramuscular dart hit, induction begins in 3-5 minutes and continues to sternal or lateral position in 8 to 12 minutes [in most deer]
- If no effect, or only a partial effect in 15 minutes, you can give a full dose again since the drugs are fully reversible
Widely used in veterinary medicine for its analgesic and anesthetic effects in small animals
Veterinarians often use ketamine in combination with sedative drugs to produce a balanced anesthesia and to prevent pain by a constant rate infusion
Ketamine has a wide and vast use in non-domestic species. More recently it has found a broader species use combined with the newer more potent alpha-two agonist medetomidine
Ketamine has a synergistic effect with medetomidine in elk, which has been reported anecdotally by many field studies
Each M-K Kit includes the following components:
Vial #1: M-K Combo 10ml Vial
Medetomidine HCl 5mg/ml & Ketamine HCl 150mg/ml
Vial #2: Atipamezole 25mg/ml 10ml Vial