• ZooPharm
  • ZooPharm
  • ZooPharm
  • ZooPharm
Yohimbine HCI (Antagonil) 30ml - 10mg/ml

Yohimbine HCI (Antagonil) 30ml - 10mg/ml

Category: WILDLIFE


Yohimbine hydrochloride is an alpha-2 antagonist indicated for the reversal of the sedative effects of xylazine in free-ranging or confined elk and deer (Cervidae). Formulated at 10 mg/ml, Yohimbine hydrochloride provides rapid and safe reversal of xylazine sedation in an easily administered, low-volume and economical dose.


Wildlife Management and Domestic

Yohimbine was first used successfully in members of the family Cervidae – elk and deer, free-ranging and confined. It has also been used to reverse xylazine in other non-domestic hoof stock with consistent predictable results varying species by species. While it may be highly effective in reversing xylazine sedation in bighorn sheep, it may produce inconsistent erratic results in other members of the family Bovidae, including certain African antelope. It has consistently reversed xylazine sedation in non-domestic members of the families Canidae and Felidae.
It has been anecdotally reported that animals that are imprinted on humans and/or that are highly tame have been refractory to the reversal effects of yohimbine on xylazine sedation.

Use in Domestic Species
One of the first alpha-two antagonists developed to provide complete reversal of anesthetic effects of xylazine hydrochloride, yohimbine is predominantly used in dogs.


The chemical name of yohimbine hydrochloride is Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, hydrochloride (1:1), (16.alpha.,17.alpha.)-
Yohimbine hydrochloride is a synthetic indole alkaloid. It is a selective competitive alpha-two-adrenergic receptor antagonist. The reversal of the sedative effects of xylazine by yohimbine is rapid, usually 2-10 minutes. Yohimbine also reverses any cardiac side-effects, such as arrhythmia and bradycardia, which may occur when xylazine is administered alone.


Yohimbine easily penetrates the blood brain barrier to block and antagonize the central nervous system depression or sedation brought on by xylazine, a potent sedative and analgesic with muscle relaxant properties. The CNS depressant effect and other pharmacologic effects are dose dependent.


Yohimbine hydrochloride is administered intravenously at a dose of 0.2-0.3 mg/kg body weight.

How Supplied:

Yohimbine hydrochloride was approved by the FDA in 2mg/ml and 5mg/ml strengths.

Yohimbine hydrochloride is compounded upon prescription in 30 ml multiple use vials. Each ml contains 10 mg of yohimbine.

Each ml contains: 10 mg yohimbine hydrochloride, 1 mg methylparaben (as a preservative), 0.30% ethyl alcohol in water for injection pH is adjusted with hydrochloric acid or sodium hydroxide.


Intrathoracic, intra-abdominal, subcutaneous or intramuscular injection is to be avoided. When using yohimbine hydrochloride in wild or exotic species, one must be prepared and knowledgeable regarding proper procedures to handle problemsresulting from animals being in lateral and sternal recumbency for extended periods of time
DO NOT USE 30 days before or during the hunting season.
DO NOT USE in domestic food-producing animals.
Hypotension and transient excitement were observed in clinical studies with yohimbine hydrochloride.


AddThis Social Bookmark Button